Welcome to your comprehensive MLB betting guide for Monday, July 21, 2025! With 15 games on the schedule, we’ve analyzed the odds, statistics, and expert insights to bring you the most promising betting opportunities across all major markets.
BEST MONEY LINE BETS
Athletics ML (+105) at Texas Rangers
Milwaukee Brewers ML (+110) at Seattle Mariners
Take the red-hot Brewers as road underdogs. Milwaukee has won 10 straight games and just completed a sweep of the Dodgers. Brandon Woodruff makes his third start of the season after an impressive return from injury (1-0, 2.61 ERA, 0.18 WHIP).
BEST RUN LINE BETS
New York Yankees -1.5 Run Line (+146) at Toronto Blue Jays
Carlos Rodon (10-6, 3.08 ERA) gives the Yankees a significant edge over Kevin Gausman (6-7, 4.19 ERA). Aaron Judge historically destroys Gausman (16-for-43 lifetime with 6 home runs), and the Yankees lineup should feast.
St. Louis Cardinals -1.5 Run Line (-115) at Colorado Rockies
The Cardinals face the league-worst Rockies (24-75) at Coors Field. Despite the hitter-friendly environment, St. Louis has value with Michael McGreevy on the mound against Austin Gomber.
Tampa Bay Rays -1.5 Run Line (-105) vs Chicago White Sox
The Rays are heavily favored for good reason against the league-worst White Sox (35-65). Shane Baz (8-5, 4.17 ERA) starts for Tampa Bay against Sean Burke (4-8, 4.36 ERA). The Rays have a 69.02% win probability according to numberFire projections.
↕️ BEST GAME TOTAL BETS
St. Louis Cardinals at Colorado Rockies UNDER 11.5 (-110)
Despite Coors Field’s reputation, this total feels inflated. Colorado averages just 3.57 runs per game (third-fewest in MLB), and the Cardinals have struggled offensively lately. McGreevy’s underlying numbers are solid with a 3.98 SIERA.
Kansas City Royals at Chicago Cubs UNDER 7.5 (-105)
Wrigley Field will have 10+ mph winds blowing in, creating pitcher-friendly conditions. Ryan Brasier opens for the Cubs while Noah Cameron starts for Kansas City. Both pitchers have shown strong NRFI tendencies.
Los Angeles Angels at New York Mets OVER 8.5 (-107)
BEST TEAM TOTAL BETS
Cleveland Guardians Team Total OVER 4.5 (+112)
The Guardians have averaged 5.9 runs per game over their last 10 contests and face struggling pitcher Tomoyuki Sugano (4.44 ERA, 5.80 expected ERA). Sugano has a horrific 7.94 ERA over his last six starts.
Arizona Diamondbacks Team Total OVER 4.5
The D-backs face Houston’s Colton Gordon, who has allowed 1.73 home runs per nine innings. Arizona’s offense should capitalize at home in Chase Field.
BEST NRFI (No Run in First Inning)
Kansas City Royals at Chicago Cubs NRFI (-125)
Pitcher-friendly conditions at Wrigley with strong winds blowing in. Ryan Brasier hasn’t allowed a home run all season, while Noah Cameron has logged NRFIs in 10 of 12 starts.
BEST PITCHER PROPS
Noah Cameron (Kansas City Royals) OVER 4.5 Strikeouts (+117) vs Chicago Cubs
Cameron has recorded 5+ strikeouts in each of his three July starts, including a career-high 8 against the Mets. The Cubs struck out 8 times in their last game, suggesting vulnerability.
BEST HOME RUN PROPS
Corbin Carroll (Arizona Diamondbacks) Home Run (+575) vs Houston Astros
Carroll hit a home run in the All-Star Game and has completely changed his approach, already hitting 21 homers this season. Colton Gordon has allowed 1.73 HR/9, which would rank 4th-worst among qualified starters.
Aaron Judge (New York Yankees) Home Run (+185) at Toronto Blue Jays
Judge historically dominates Kevin Gausman and has the power to take advantage of any mistake pitches. Despite Toronto potentially pitching around him, his track record makes him a strong play.
Ketel Marte (Arizona Diamondbacks) Home Run (+310) vs Houston Astros
Arizona’s All-Star has been scorching hot and faces Colton Gordon, who struggles with the long ball. Marte should have multiple opportunities in the heart of the D-backs lineup.
Teoscar Hernandez (Los Angels Dodgers) Home Run (+375) vs Minnesota Twins
The Dodgers slugger has been consistent all season and faces David Festa in a favorable matchup at Dodger Stadium.
2️⃣ BEST 2-LEG PARLAY OF THE DAY (+292)
St. Louis Cardinals -1.5 Run Line (-115)
Milwaukee Brewers ML (+110)
1 UNIT Play Estimated Combined Odds: $100 bet potential win $292
3️⃣ BEST 3-LEG PARLAY OF THE DAY (+740)
- Athletics ML (+105)
- Kansas City Royals at Chicago Cubs UNDER 7.5 (-105)
- Milwaukee Brewers ML (+110)
1 UNIT Play Estimated Combined Odds: $100 bet potential win $740
This parlay targets three quality teams with pitching advantages and strong recent form. The Brewers’ 10-game winning streak anchors the play.
This parlay combines strong moneyline favorites with targeted prop plays, offering solid return potential with manageable risk.
Weather Considerations:
- Wrigley Field: 10+ mph winds blowing in (favorable for under/NRFI)
- Chase Field: Dome environment, no weather concerns
- Most outdoor games: Clear conditions expected
Remember to bet responsibly and within your limits. These picks are based on current odds and analysis – always verify lines before placing bets as they may change throughout the day.
